Antisperm Antibodies

I understand that antisperm antibodies reduce the chance of conception but if conception occurs can the antibodies cause a higher chance of miscarriage? Also at what percentage of antibodies does natural conception become virtually impossible? I have found it very difficult to find any reliable information on antisperm antibodies out there so any information is welcome! Thanks

Our Expert's Answer

This information was published 7 years, 8 months ago and was correct at the time of publication. It may not reflect our current practices or regulations.

Please note that all the answers we give are on a generic basis only, as we cannot provide more in-depth answers without access to your medical history. If you need a more detailed response, tailored to you, we would recommend a consultation with one of our Fertility Specialists for more comprehensive medical advice.

Antisperm antibodies (ASA) cause problems with sperm transport through the female reproductive tract and in sperm-egg interaction.  In an ejaculated sample ASA’s can cause the sperm to stick together and this can reduce the number of motile sperm in the sample.  There is no link between ASA’s and miscarriage.  The level of antibodies varies between samples and at high levels they will reduce the chance of conception.