Modified Natural Cycle IVF

IVF that is synced to your natural menstrual cycle with lower doses of medication

Modified natural cycle IVF is a low-stimulation IVF protocol that uses reduced doses of fertility medication compared to conventional treatment.
It is typically recommended for patients with very low ovarian reserve or those who have responded poorly to standard IVF stimulation.
The approach aims to support the development of at least one follicle, followed by ovulation triggering, egg collection and embryo transfer as in conventional IVF.
Because fewer eggs are produced, there may be limited embryos available and multiple treatment cycles may be required to achieve pregnancy.
This protocol has lower success rates and a higher likelihood of cycle cancellation, so it is only recommended for carefully selected patients.
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Modified Natural Cycle IVF is simply an IVF protocol where lower doses of fertility drugs are used to stimulate the ovaries compared to conventional IVF.

This type of IVF is designed for patients with extremely low ovarian reserve, which means a very low number of eggs in the ovary to begin with. It is an option where standard doses of drugs would not yield any more eggs than with the modified natural regime.

The final cost of your Modified Natural IVF treatment will depend on your circumstances, existing medical conditions, and overall health or you and your partner.

Your treatment plan will be personalised to your individual needs. As such, your treatment plan may incur additional fees. A member of our expert team will consult with you on any add-ons they consider necessary for your treatment. For more information on potential add-ons, see our latest price list.

Here at Manchester Fertility, we're open about the cost of our treatments; we aim to reduce the risk of surprise bills later down the line and offer you higher-quality treatment at a reasonable, transparent price. Although we're confident that our Modified Natural Cycle IVF package accounts for a considerable amount of your treatment expenses, such as consultations, screening tests or monitoring scans, we still recommend that you read our pricing information thoroughly or contact our New Patient team directly on 0161 300 2737 if you have any questions.

*Additional fees may apply

Consultation with a Fertility Specialist

The Manchester Fertility team will start by giving an ultrasound scan to both partners, assessing fertility and discussing the results in a consultation.

Blood Tests and Assessments

At this stage we address your general health and your individual needs to ensure Modified Natural Cycle IVF is the right choice for you. For example we may be looking for a low ovarian reserve.

Modified Ovarian Stimulation

The first stage of IVF is ovarian stimulation. This involves using tailored doses of fertility drugs to help you produce mature eggs. In the case of Modified Natural IVF we use a smaller amount of medication to stimulate fewer eggs.

Egg Maturation

A ‘trigger’ injection of fertility medications – human Chorionic Gonadotrophin (hCG) or GnRH analogue or both – is administered to assist with the final maturation of your egg and loosening of the egg from the follicle walls.

Egg Collection

Around 35-38 hours after the ‘trigger’ injection, egg retrieval takes place in our clinic theatre under ultrasound guidance and conscious sedation. The egg is retrieved from the follicles where it has been growing.

Insemination of Eggs

We then prepare the sperm you will be using for treatment, this could be sperm from a partner or a donor. The sperm sample is washed and prepared, then added to the egg approximatly four hours after egg retrieval.

Embryo Transfer

Our embryologists then observe your embryo for the next two to five days, if fertilisation is successful and the embryo remains healthy it is transferred under ultrasound guidance into your uterus by our fertility consultants, in our specially-designed embryo transfer room.

Pregnancy Test

You can take a home pregnancy test around two weeks after your embryo transfer. During this time, you will be supported by our clinic midwife. If your test is positive, you will be booked in for your pregnancy confirmation scan at 6-7 weeks of pregnancy

Our fertility specialists may recommend Modified Natural IVF if you have responded poorly to IVF stimualtion is previous treatment cycles or if you have a relatively low ovarian reserve.

You may also wish to consider Natural Modified IVF is you have a significant family history of breast, ovarian or other oestrogen dependent cancers - your expert fertility consultant will be able to discuss this with you before you commit to treatment.

At Manchester Fertility we only recommend Modified Natural Cycle IVF for very few patients, we will discuss with you whether it is something you could consider, based on your individual test results and previous treatment history. We would only recommend it as an option if we think it gives you a good chance of success

Advantages of Modified Natural Cycle IVF

Reduced risks and fewer side effects
Reduced risk of Ovarian Hyperstimulation Syndrome (OHSS)
More affordable treatment costs

Disdvantages of Modified Natural Cycle IVF

Although more gentle on the body, Modified Natural Cycle IVF does have lower success rates to other alternate IVF treatments
There is a lower chance of having additional embryos for freezing or for additional treatment cycles
You may need to have multiple cycles

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