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Non-invasive prenatal chromosome testing (NIPT)

Pregnant but worried about possible chromosome conditions? We offer the very latest in non-invasive prenatal testing which assesses the risks of conditions such as Down’s Syndrome. Noninvasive prenatal tests like PrenatalSafe NIPT have been shown to perform better than traditional prenatal screening methods, and they avoid the risk of miscarriage associated with invasive diagnostic procedures such as amniocentesis and chorionic villus sampling (CVS).

Anyone can come to us for this test, whether you’ve had successful treatment with us, at another clinic, or have conceived naturally.

What is the PrenatalSafe Non-Invasive Test?

The PrenatalSafe non-invasive test is a simple, non-invasive blood test. Available from 10 weeks of pregnancy, it involves a sample of your blood being taken by our nurses at our clinic. This sample is then sent for analysis to a specialist laboratory in the UK.

The test determines the risk to your baby of various Trisomies - chromosome conditions caused by three copies of a particular chromosome instead of two. DNA circulates from your baby in your own blood during pregnancy, PrenatalSafe analyses this DNA via your own blood.

The test assesses the risks of:

How does it work?

The Non-invasive prenatal NIPT test from The Genoma Group is the most sensitive, validated and safe test available and it is simply a single blood test taken from the mothers arm. In pregnancy, some fragments of the fetal DNA circulate in the maternal bloodstream and are even detectable as early as week 5 of the pregnancy. The quantity increases as the age of the pregnancy increases and from the 10th week of pregnancy, there is a sufficient quantity to guarantee an accurate result.

One vial of blood is collected and sent to the state of the art laboratory in Italy. The test is available for singleton and twin pregnancies and all IVF pregnancies. The reliability and sensitivity of the test is outstanding with the test being reliable at even a low fetal fraction (FF>2%) with an incidence of false positives of <0.1%. The latest data shows an incidence rate of 0% false negatives. The test is well validated with performance data published in leading scientific journals. A clinical validation study was performed on a cohort of over 12,000 pregnant women.

How many different PrenatalSafe tests are there?

PrenatalSafe testing is offered as four different test 'panels', providing options to accommodate every patient’s unique situation.


How accurate is the result of the PrenatalSafe NIP Test?

PrenatalSafe is an early and highly-accurate test which unlike traditional testing such as amniocentesis or CVS carries no risk to your baby. Studies show it is over 99% accurate for assessing Down’s Syndrome risk. The false positive and false negative results are also significantly lower than traditional invasive testing methods with a combined false positive rate for Trisomy 21, 18 and 13 of just 0.15%.

How long does the test take and how much does it cost?

Depending upon which PrenatalSafe test you choose, your results will usually be available within 5-7 working days from receipt of the test at the laboratoy, typically around the time you would go for your first trimester 12 week scan. 

Deciding if the test is right for you

PrenatalSafe does not detect all fetal abnormalities. If your test result shows a high risk that your baby has a chromosome condition, it is not a definite diagnosis, although the accuracy of the PrenatalSafe test means it’s highly unlikely your test result would be inaccurate. In the event of a positive result, you will be referred back to your NHS care provider for follow-up testing. 

Serenity NIPT Manchester Fertility

Want to know more?

If you’d like to know more about the range of PrenatalSafe tests available at Manchester Fertility, please contact our Patient Advisors on 0161 300 2730 or email us.

You can also find useful information on PrenatalSafe and PrenatalSafe Karyo

* Warburton D, DallaireL, ThangaveluM, Ross L, Levin B, Kline J. Trisomy recurrence: a reconsideration based on North American data. Am J Hum Genet 2004;75(3):376-85.
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