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Non-invasive prenatal chromosome testing (NIPT)

Pregnant but worried about possible chromosome conditions? We offer the very latest in non-invasive prenatal testing which assesses the risks of conditions such as Down’s Syndrome.

Anyone can come to us for this test, whether you’ve had successful treatment with us, at another clinic, or have conceived naturally.

Serenity NIP Test

What is the Serenity Non-Invasive Prenatal Test?

The new Serenity non-invasive prenatal test is a simple, non-invasive blood test. Available from 10 weeks of pregnancy, it involves a sample of your blood being taken by our nurses at our clinic. This sample is then sent for analysis to a specialist laboratory in the UK.

The test determines the risk to your baby of various Trisomies - chromosome conditions caused by three copies of a particular chromosome instead of two. DNA circulates from your baby in your own blood during pregnancy, Serenity analyses this DNA via your own blood.

The Serenity test assesses the risks of:

How accurate is the result of the Serenity NIP Test?

Serenity is an early and highly-accurate test which unlike traditional testing such as amniocentesis or CVS carries no risk to your baby. Studies show it is over 99% accurate for assessing Down’s Syndrome risk. The false positive and false negative results are also significantly lower than traditional invasive testing methods with a combined false positive rate for Trisomy 21, 18 and 13 of just 0.15%.

How long does the test take and how much does it cost?

Your results will be available within 3-5 working days from testing, typically around the time you would go for your first trimester 12 week scan. The Serenity NIP test is available for £495.

Deciding if the test is right for you

Serenity does not detect all fetal abnormalities. If your test result shows a high risk that your baby has a chromosome condition, it is not a definite diagnosis, although the accuracy of the Serenity test means it’s highly unlikely your test result would be inaccurate. In the event of a positive result, you’ll be referred back to your NHS care provider for follow-up testing.


Serenity 24 - screening for all 24 Chromosomes

The new Serenity 24 NIPT offers highly accurate and reliable detection of aneuploidy in all 24 chromosomes from a simple blood sample, providing a broader range of information about the health of a pregnancy.

Why screen all Chromosomes?

Chromosomal aneuploidies are the leading cause of miscarriage and, in pregnancies that go to term, can have a significant impact on physical and intellectual well-being.1 Traditionally, prenatal screening has been restricted to the most common live birth aneuploidies (trisomies 21, 18, and 13).

By expanding the scope of noninvasive prenatal testing to include rare autosomal trisomies (RATs), healthcare providers have the opportunity to identify these anomalies as early as 10 weeks pregnancy and better inform:

• Medical management of pregnancy - including clinical considerations for confined placental mosaicism (CPM) and uniparental disomy (UPD)

• Recurrence risks & future pregnancy management - There is a 1.8x higher risk of aneuploidy in a future pregnancy when a rare autosomal trisomy is identified in a prior loss. *

Serenity 24 is the only test offering all chromosome screening for both singleton and twin pregnancies. The test utilises an extensively validated and proprietary analysis software to deliver best possible results for your patients. All Serenity 24 samples are tested at a state-of-the-art laboratory in London. Serenity 24 test results are usually available in 3-5 days post receipt of the sample in the testing laboratory.

If you’d like to know more about the Serenity NIP Test or Serenity 24 at Manchester Fertility, please contact our Patient Advisors on 0161 300 2730

* Warburton D, DallaireL, ThangaveluM, Ross L, Levin B, Kline J. Trisomy recurrence: a reconsideration based on North American data. Am J Hum Genet 2004;75(3):376-85.
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