Endometrial Receptivity Array Test (ERA)
We’re one of the leading providers of Endometrial Receptivity Array Test (ERA) in Manchester.
What is the Endometrial Receptivity Array Test?
This genetic test is a revolutionary new method of assessing when the endometrium (the membrane that lines the inside of your uterus) is receptive to the embryo, in order to give a personalised embryo transfer. This technique helps evaluate your endometrial receptivity from a molecular perspective and analyses sequencing expression of 236 genes involved in the endometrial receptivity.
When is it recommended and why?
Your endometrium is receptive when it is ready for the embryo implantation. This occurs around days 19-21 in each menstrual cycle of a fertile woman. This period of receptivity is called the window of implantation.
Until recently there has been no way of accurately assessing whether the endometrium is at its most receptive.
This technique may be particularly useful for patients with repeated implantation failure. A displaced window of implantation is detected in approximately 25% of these patients.
This analysis helps determine the personalised window of implantation, enabling personalized embryo transfer (pET) to be performed on the basis of these results.
What is the process?
To perform this analysis it is necessary to take an endometrial biopsy from women in their natural cycle or hormone replacement therapy cycles, at a time corresponding to the phase of endometrial receptivity.
That is, in the natural cycle, seven (7) days after the LH (luteinizing hormone) surge OR after five (5) full days of progesterone supplementation in Hormone replacement therapy (HRT) cycles. After the biopsy is taken it is immediately introduced into a tube which contains a fluid that facilitates the preservation of the tissue.
What are the advantages of ERA?
The receptivity of the endometrium is a crucial factor in determining the success of IVF treatment. This test indicates the window of implantation, increasing your chances of successful embryo transfer and achieving high success rates to our patients.
This test has shown not to discriminate between fertile and infertile patients and it does not guarantee a successful outcome after personalised embryo transfer (pET).
If you’d like to know more about the Endometrial Receptivity Array Test at Manchester Fertility, contact our Patient Advisors on 0161 300 2730.
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