IVF endometriosis and PCOS

I had my first round of IVF in March. We got 8 eggs. First cycle I miscarried at 4 weeks. It was one embryo. Second round was in July. I miscarried at 5 weeks. My endometriosis is grade 3. Although I have PCOS, I have regular periods and doctor says I have syndrome but no symptoms. They transferred 2 embryos. I am 39. At this stage we have 5 eggs frozen. We are both broken hearted. What would you advise now? My BMI is 26.

Our Expert's Answer

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I am so sorry that you have had two miscarriages. Unfortunately endometriosis can affect implantation of the embryo. I would recommend that you have a thyroid function and antibody tests and any abnormal results can be easily corrected. Before you have further treatment I would advise having an endometrial scratch, then have a hormonally regulated cycle with Quad therapy (Progesterone, Prednisolone, LMWH like Clexane and later Aspirin). You both may benefit from counselling for emotional support.